Description

1-Trifluoromethylsulfanyl-Propan-2-One is a specialized organosulfur and organofluorine compound featuring a trifluoromethylthio (SCF₃) functional group. This high-value building block is prized for its ability to introduce the lipophilic and metabolically stable SCF₃ moiety into target molecules, significantly altering their physicochemical properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the trifluoromethylthio group into drug candidates to enhance membrane permeability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the SCF₃ group can improve biological activity and environmental persistence.
• Material Science Research: Employed in the development of specialty polymers and advanced materials with unique surface properties or reactivity.
• Fluorine Chemistry: Serves as a versatile reagent in academic and industrial laboratories for exploring new fluorination methodologies and creating fluorine-containing compound libraries.

Basic Information

Product Name	1-Trifluoromethylsulfanyl-Propan-2-One
CAS No.	42105-30-6
Molecular Formula	C₄H₅F₃OS
Molecular Weight	158.14 g/mol
Synonyms	2-Propanone, 1-(trifluoromethylthio)-; 1-(Trifluoromethylthio)acetone; 3-Oxo-1-(trifluoromethylthio)propane; S-Trifluoromethyl Thioglycolic Acid Methyl Ester; Acetone, (trifluoromethylthio)-; Trifluoromethylthioacetone; SCF₃-Acetone
EINECS	Contact for details

Quality Control

Every batch of 1-Trifluoromethylsulfanyl-Propan-2-One is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and development applications. A detailed Certificate of Analysis (COA) confirming identity, purity (typically by GC or HPLC), and impurity profile is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.