Description

trans-2-Isopropyl-5-Carboxy-1,3-Dioxane is a specialized heterocyclic building block featuring a dioxane ring with both isopropyl and carboxylic acid functional groups. This compound is valued for its unique stereochemistry and bifunctional reactivity, making it a versatile intermediate in advanced organic synthesis. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, such as chiral ligands, prodrugs, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in developing central nervous system (CNS) agents and antiviral compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its structure contributes to specific biological activity.
• Chiral Ligand/ Catalyst Precursor: Serves as a starting material for the development of asymmetric catalysts used in enantioselective synthesis.
• Complex Molecule Construction: Employed in academic and industrial R&D for building complex, oxygen-containing heterocycles and natural product analogs.
• Polymer Modification: Potential use as a monomer or cross-linking agent for creating specialty polymers with tailored properties.
• Chemical Research: A valuable reference standard and building block in methodological chemistry studies exploring new synthetic pathways.

Basic Information

Product Name	trans-2-Isopropyl-5-Carboxy-1,3-Dioxane
CAS No.	42031-28-7
Molecular Formula	C8H14O4
Molecular Weight	174.19 g/mol
Synonyms	5-Carboxy-2-(1-methylethyl)-1,3-dioxane, trans-; 2-Isopropyl-5-carboxy-1,3-dioxane; 1,3-Dioxane-5-carboxylic acid, 2-(1-methylethyl)-, trans-; (trans)-2-Isopropyl-1,3-dioxane-5-carboxylic Acid; trans-2-(Propan-2-yl)-1,3-dioxane-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our trans-2-Isopropyl-5-Carboxy-1,3-Dioxane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and Karl Fischer titration for moisture content. We provide a Certificate of Analysis (COA) with every shipment, detailing all specifications and test results to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.