Description

tert-Butyl Trimethylsilylacetate is a versatile organosilicon reagent that serves as a protected acetate synthon. This compound matters for its utility in advanced organic synthesis, particularly in the construction of complex molecules where selective deprotection is required. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as peptide coupling and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Key intermediate in the multi-step synthesis of complex pharmaceuticals and bioactive molecules.
• Protected carboxylic acid equivalent in peptide coupling and solid-phase peptide synthesis (SPPS).
• Building block for the preparation of silicon-containing polymers and advanced materials.
• Reagent in organic transformations requiring a robust protecting group for acetic acid derivatives.
• Used in the development of agrochemicals and other fine chemicals.
• Starting material for the synthesis of specialized esters and other functionalized compounds in research settings.

Basic Information

Product Name	tert-Butyl Trimethylsilylacetate
CAS No.	41108-81-0
Molecular Formula	C9H20O2Si
Molecular Weight	188.34 g/mol
Synonyms	Acetic acid, 2-(trimethylsilyl)-, 1,1-dimethylethyl ester; 2-(Trimethylsilyl)acetic acid tert-butyl ester; tert-Butyl 2-(trimethylsilyl)acetate; TBSA-OtBu; Trimethylsilylacetic acid tert-butyl ester; (Trimethylsilyl)acetic Acid tert-Butyl Ester; tert-Butyl (trimethylsilyl)acetate
EINECS	Contact for details

Quality Control

Our tert-Butyl Trimethylsilylacetate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including GC, NMR, and IR spectroscopy, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.