Description

[(2R,3R)-2-[(Dichloroacetyl)Amino]-3-(4-Nitrophenyl)-3-[(Trimethylsilyl)Oxy]Propyl]2-O,3-O,4-o-Tris(Trimethylsilyl)-β-D-Glucopyranosiduronic Acid Methyl Ester is a sophisticated, high-purity synthetic intermediate of significant importance in advanced organic synthesis. This compound is specifically engineered for applications requiring precise stereochemistry and protected functional groups, making it a critical building block for complex molecule construction. It is primarily sought after by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs), complex carbohydrate derivatives, and specialized chemical probes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for complex, multi-step synthetic routes.
• Glycochemistry Research: Serves as a protected glucuronic acid derivative for studying glycosylation reactions, enzyme inhibitors, and carbohydrate-based drug design.
• Chemical Biology Probes: Used in the synthesis of labeled or tagged compounds for investigating biological pathways and target engagement.
• Process Chemistry Development: Employed in scaling up synthetic pathways from laboratory to pilot plant scale for potential commercial drug candidates.
• Academic & Institutional Research: A valuable reagent for universities and R&D centers exploring new synthetic methodologies and complex natural product synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific advanced intermediates.

Basic Information

Product Name	[(2R,3R)-2-[(Dichloroacetyl)Amino]-3-(4-Nitrophenyl)-3-[(Trimethylsilyl)Oxy]Propyl]2-O,3-O,4-o-Tris(Trimethylsilyl)-β-D-Glucopyranosiduronic Acid Methyl Ester
CAS No.	40619-05-4
Molecular Formula	C33H53Cl2NO13Si4
Molecular Weight	877.51 g/mol
Synonyms	Methyl (2R,3R)-2-[(dichloroacetyl)amino]-3-(4-nitrophenyl)-3-[(trimethylsilyl)oxy]propyl 2,3,4-tri-O-trimethylsilyl-β-D-glucopyranosiduronate; Methyl 2,3,4-tri-O-trimethylsilyl-1-O-[(2R,3R)-2-(dichloroacetamido)-3-(4-nitrophenyl)-3-(trimethylsilyloxy)propyl]-β-D-glucopyranosiduronate; Protected Glucuronic Acid Methyl Ester Derivative; TMS-protected Glucuronide Intermediate; CAS 40619-05-4
EINECS	Contact for details

Quality Control

Every batch of this high-value intermediate is produced and tested under strict quality management protocols to ensure identity, purity, and consistency. Our standard specification includes comprehensive analytical characterization using techniques such as HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support development projects requiring specific impurity profiles or custom specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.