Description

(R)-(+)-1,2-Propanediol Di-p-Tosylate CAS NO 40299-67-0 is a high-purity chiral building block and key synthetic intermediate. Its value lies in its role as a versatile tosylating agent for introducing the (R)-propylene oxide moiety, enabling the stereoselective synthesis of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries developing active pharmaceutical ingredients (APIs), chiral ligands, and advanced materials.

Application

• Pharmaceutical Intermediate: Critical for the stereoselective synthesis of chiral drugs, particularly in constructing propylene oxide-based side chains for β-blockers, antifungals, and other therapeutic agents.
• Asymmetric Synthesis: Serves as a pivotal reagent for introducing chiral centers in the production of non-racemic compounds for agrochemicals and specialty chemicals.
• Ligand and Catalyst Preparation: Used in the development of chiral ligands for asymmetric catalysis and organometallic complexes.
• Polymer Chemistry: Acts as a monomer or chain-transfer agent in the synthesis of stereoregular polymers with specific optical properties.
• Academic and R&D: A valuable tool for methodological development in organic synthesis and medicinal chemistry research within university and corporate laboratories.
• Fine Chemical Production: Employed in the multi-step synthesis of high-value, optically pure flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	(R)-(+)-1,2-Propanediol Di-p-Tosylate
CAS No.	40299-67-0
Molecular Formula	C19H22O6S2
Molecular Weight	410.50 g/mol
Synonyms	(R)-(+)-1,2-Di-p-tosyloxypropane; (R)-Propylene Glycol Ditosylate; (R)-1,2-Propanediol Bis(4-methylbenzenesulfonate); (R)-(+)-1,2-Bis(4-toluenesulfonyloxy)propane; D-1,2-Propanediol Di-p-toluenesulfonate; (R)-PGDT; (2R)-1,2-Bis[(4-methylphenyl)sulfonyl]oxypropane; (R)-1,2-Ditosyloxypropane
EINECS	Contact for details

Quality Control

Every batch of our (R)-(+)-1,2-Propanediol Di-p-Tosylate is manufactured under strict quality management systems. We employ advanced analytical techniques, including chiral HPLC, to guarantee high enantiomeric purity and chemical identity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with full analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.