Description

5-Bromo-2-furonitrile is a versatile halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in the reactive bromine and nitrile functional groups, which allow for selective cross-coupling reactions and further functionalization to create complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the furan ring system contributes to biological activity.
• Material Science Precursor: Serves as a monomer or building block for the synthesis of specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings to form carbon-carbon and carbon-heteroatom bonds.
• Nitrile Functionalization: The nitrile group can be hydrolyzed to carboxylic acids, reduced to amines, or used in cycloaddition reactions to form heterocycles like tetrazoles.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodology development and exploring new synthetic pathways.

Basic Information

Product Name	5-Bromo-2-furonitrile
CAS No.	4915-06-4
Molecular Formula	C5H2BrNO
Molecular Weight	171.98 g/mol
Synonyms	2-Bromo-5-cyanofuran; 5-Bromo-2-cyanofuran; 2-Furonitrile, 5-bromo-; 5-Bromofuran-2-carbonitrile; 5-Bromo-2-furancarbonitrile; 5-Bromofuro[2,3-c]pyridine? (Incorrect, verify); Bromofuronitrile
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-furonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber or opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.