Description

n-Tosyl-L-Aspartic Acid is a protected derivative of the essential amino acid L-aspartic acid, where the amine group is shielded by a tosyl group. This modification is crucial for its primary role as a key chiral building block and intermediate in the synthesis of complex peptides, pharmaceuticals, and fine chemicals. It is an essential material for research institutions and manufacturers in the pharmaceutical, biotechnology, and advanced organic synthesis sectors who require high-purity, stereochemically defined intermediates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptides and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected aspartic acid residue to prevent unwanted side reactions during coupling.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and for probing the active sites of aspartic proteases.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, catalysts, and ligands where precise stereochemistry is required.
• Protecting Group Chemistry: The tosyl group can be selectively removed under specific conditions, making it valuable in multi-step synthetic routes.

Basic Information

Product Name	n-Tosyl-L-Aspartic Acid
CAS No.	4816-82-4
Molecular Formula	C11H13NO6S
Molecular Weight	287.29 g/mol
Synonyms	N-(p-Toluenesulfonyl)-L-aspartic acid; L-Aspartic acid, N-[(4-methylphenyl)sulfonyl]-; Tosyl-L-aspartic acid; N-Tosyl-L-aspartate; N-p-Tosyl-L-aspartic acid; (2S)-2-[(4-Methylphenyl)sulfonylamino]butanedioic acid; H-Asp(OtBu)-OTos; N-Tosyl-aspartic acid
EINECS	Contact for details

Quality Control

Our n-Tosyl-L-Aspartic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical and research applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.