Description

N-(p-Tolylsulphonyl)-L-Glutamic Acid is a high-purity, specialty amino acid derivative characterized by its tosyl-protected glutamic acid structure. This compound is a critical chiral building block and intermediate in the synthesis of complex pharmaceutical actives and fine chemicals, offering precise stereochemical control. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in peptide synthesis and the production of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of peptide-based drugs and bioactive molecules.
• Peptide Chemistry: Serves as a protected glutamic acid derivative for solid-phase and solution-phase peptide synthesis.
• Biochemical Research: Used as a standard or reagent in enzymatic studies and metabolic pathway research.
• Fine Chemical Synthesis: An intermediate for creating more complex, high-value specialty chemicals with specific stereochemistry.
• Protecting Group Strategy: The tosyl (p-toluenesulfonyl) group provides a stable protecting group for the amino function in complex organic syntheses.

Basic Information

Product Name	N-(p-Tolylsulphonyl)-L-Glutamic Acid
CAS No.	4816-80-2
Molecular Formula	C12H15NO6S
Molecular Weight	301.32 g/mol
Synonyms	N-(4-Methylphenyl)sulfonyl-L-glutamic acid; L-Glutamic acid, N-[(4-methylphenyl)sulfonyl]-; Tosyl-L-glutamic acid; N-Tosyl-L-glutamic acid; N-p-Toluenesulfonyl-L-glutamic acid; (2S)-2-[(4-Methylphenyl)sulfonylamino]pentanedioic acid; N-(Tosyl)-L-glutamic acid; NSC 3347
EINECS	Contact for details

Quality Control

Our N-(p-Tolylsulphonyl)-L-Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and fine chemical synthesis. A Certificate of Analysis (COA) detailing identity, purity, and specific tests is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.