Description

3-Isothiazolecarboxylic Acid CAS NO 4576-90-3 is a versatile heterocyclic carboxylic acid building block, prized for its role as a key intermediate in the synthesis of complex molecules. Its value lies in enabling the introduction of the isothiazole pharmacophore, a core structure associated with a range of biological activities. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those working on novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing the isothiazole moiety for potential antimicrobial, anti-inflammatory, or CNS-targeting drugs.
• Agrochemical Synthesis: Used in the research and production of advanced fungicides, herbicides, and insecticides, where the isothiazole ring contributes to the compound's bioactivity and stability.
• Material Science Research: Serves as a building block for creating novel polymers, ligands for metal complexes, or functional materials with specific electronic or photophysical properties.
• Chemical Biology & Proteomics: Employed as a derivatization agent or a scaffold for developing chemical probes to study enzyme function or protein interactions.
• Dye & Pigment Intermediate: Acts as a starting material for synthesizing specialized heterocyclic dyes and organic pigments.

Basic Information

Product Name	3-Isothiazolecarboxylic Acid
CAS No.	4576-90-3
Molecular Formula	C4H3NO2S
Molecular Weight	129.14 g/mol
Synonyms	1,2-Thiazole-3-carboxylic acid; Isothiazole-3-carboxylic acid; 3-Carboxyisothiazole; 3-Isothiazolecarboxylic acid; 1,2-Thiazole-3-carboxylic acid; 3-Carboxy-1,2-thiazole; 3-Isothiazolylcarboxylic acid
EINECS	Contact for details

Quality Control

Our 3-Isothiazolecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (by HPLC), identification (IR), and impurity profiles. Our quality commitment supports applications requiring high-purity chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.