Description

2-Chloro-5-Nitro-Benzenesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both a sulfonyl chloride and a nitro-substituted aromatic ring, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drugs, including diuretics, carbonic anhydrase inhibitors, and antiviral agents.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and pesticides, where the sulfonamide moiety contributes to biological activity.
• Dyestuff and Pigment Production: Serves as an intermediate for creating azo dyes and other complex colorants due to its reactive sites.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the production of specialty polymers, such as polyelectrolytes and engineering plastics.
• Chemical Research & Development: A valuable reagent for introducing the benzenesulfonyl group into target molecules in medicinal and process chemistry.
• Ligand and Catalyst Preparation: Utilized in the synthesis of specialized ligands for metal complexes used in catalytic processes.

Basic Information

Product Name	2-Chloro-5-Nitro-Benzenesulfonyl Chloride
CAS No.	4533-95-3
Molecular Formula	C6H3Cl2NO4S
Molecular Weight	256.06 g/mol
Synonyms	2-Chloro-5-nitrobenzenesulfonyl chloride; 5-Nitro-2-chlorobenzenesulfonyl chloride; 2-Chloro-5-nitrobenzene-1-sulfonyl chloride; Benzenesulfonyl chloride, 2-chloro-5-nitro-; NSC 403107; 1-Chloro-2-nitro-4-(chlorosulfonyl)benzene; 4-Chloro-3-nitrobenzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Nitro-Benzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under dry conditions to prevent hydrolysis. Keep away from strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	68 - 72 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.