Description

1-(Trimethylsilyl)-4-Nitrobenzene is a specialized organosilicon compound featuring a nitrobenzene core functionalized with a trimethylsilyl group. This unique structure makes it a valuable synthetic intermediate and protecting group reagent in advanced organic synthesis, particularly for pharmaceuticals and agrochemicals. It is primarily used by research chemists and process development scientists in fine chemical and active pharmaceutical ingredient (API) manufacturing.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, especially those requiring silicon-containing moieties or protected aromatic amines.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where its functional groups enable specific structural modifications.
• Material Science Research: Serves as a precursor for creating functionalized aromatic compounds used in organic electronic materials and advanced polymers.
• Protecting Group Chemistry: The trimethylsilyl group can act as a protective group for sensitive functionalities during multi-step synthetic sequences.
• Cross-Coupling Reactions: Utilized as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl structures.
• Laboratory Reagent: Employed in academic and industrial R&D settings for method development and exploring new synthetic pathways.

Basic Information

Product Name	1-(Trimethylsilyl)-4-Nitrobenzene
CAS No.	4405-33-8
Molecular Formula	C9H13NO2Si
Molecular Weight	195.29 g/mol
Synonyms	4-Nitrophenyltrimethylsilane; (4-Nitrophenyl)trimethylsilane; Trimethyl(4-nitrophenyl)silane; p-Nitrophenyltrimethylsilane; 4-(Trimethylsilyl)nitrobenzene; TMS-Nitrobenzene; NSC 163083
EINECS	Contact for details

Quality Control

Our 1-(Trimethylsilyl)-4-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance. Standard quality parameters include assay by HPLC, identity confirmation by FT-IR and NMR, and control of key impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.