Description

4-Cyanotetrahydro-4H-Pyran is a versatile heterocyclic building block featuring both a nitrile group and a tetrahydropyran ring. This compound is valued for its bifunctional reactivity, serving as a key intermediate in the synthesis of complex pharmaceutical molecules and advanced agrochemicals. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides, where the tetrahydropyran moiety can enhance biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers and functional polymers with specific thermal or optical properties.
• Fine Chemical Production: Acts as a building block for dyes, flavors, and fragrances requiring specific heterocyclic frameworks.

Basic Information

Product Name	4-Cyanotetrahydro-4H-Pyran
CAS No.	4295-99-2
Molecular Formula	C6H9NO
Molecular Weight	111.14 g/mol
Synonyms	4-Cyanotetrahydropyran; Tetrahydro-4H-pyran-4-carbonitrile; 4-Pyrancarbonitrile, tetrahydro-; 4-Cyanooxane; Oxane-4-carbonitrile; 4-Cyanotetrahydro-2H-pyran; 4-Cyanotetrahydropyran-4-carbonitrile (incorrect but common search variant)
EINECS	Contact for details

Quality Control

Our 4-Cyanotetrahydro-4H-Pyran is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.