Description

2β,4α-Diphenyl-1β,3α-Cyclobutanedicarboxylic Acid CAS NO 490-20-0 is a high-value, stereochemically defined cyclobutane derivative, serving as a critical chiral building block and synthetic intermediate in advanced organic synthesis. Its rigid, multi-functional structure makes it indispensable for constructing complex molecular architectures with precise spatial orientation. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where its stereochemistry influences biological activity.
• Ligand & Catalyst Development: Serves as a backbone for creating chiral ligands used in asymmetric catalysis (e.g., hydrogenation, cross-coupling reactions).
• Advanced Material Monomer: A building block for high-performance polymers, liquid crystals, and organic electronic materials requiring specific geometric constraints.
• Academic & Process Chemistry Research: A valuable compound for methodological studies in stereoselective synthesis and cycloaddition chemistry.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals.

Basic Information

Product Name	2β,4α-Diphenyl-1β,3α-Cyclobutanedicarboxylic Acid
CAS No.	490-20-0
Molecular Formula	C18H16O4
Molecular Weight	296.32 g/mol
Synonyms	(1R,2S,3R,4S)-1,3-Dicarboxy-2,4-diphenylcyclobutane; (1β,2β,3α,4α)-1,3-Dicarboxy-2,4-diphenylcyclobutane; trans,trans-2,4-Diphenylcyclobutane-1,3-dicarboxylic Acid; (±)-trans,trans-2,4-Diphenylcyclobutane-1,3-dicarboxylic Acid; 2,4-Diphenylcyclobutane-1,3-dicarboxylic Acid; Cyclobutane-1,3-dicarboxylic acid, 2,4-diphenyl-; DL-2,4-Diphenylcyclobutane-1,3-dicarboxylic Acid
EINECS	207-707-3

Quality Control

Our production of 2β,4α-Diphenyl-1β,3α-Cyclobutanedicarboxylic Acid adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. Every lot is fully characterized using advanced analytical techniques, including HPLC, NMR, and chiral analysis, to confirm identity, stereochemical purity, and impurity profile. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de (diastereomeric excess)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.