Description

(-)-3,4-Dihydro-3-Hydroxy-7-(5-Methoxy-2,2-Dimethyl-2H-1-Benzopyran-6-Yl)-2,2-Dimethyl-2H,6H-Benzo[1,2-B:5,4-B']Dipyran-6-One is a high-purity, optically active benzopyran derivative with a complex fused ring structure. This compound is valued for its role as a key chiral intermediate in advanced organic synthesis, particularly for pharmaceuticals and fine chemicals. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders or with complex stereochemical requirements.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging its unique benzopyran scaffold.
• Fine Chemical Synthesis: Acts as a precursor for synthesizing complex natural product analogs, flavors, and fragrances.
• Academic & Industrial R&D: Employed in methodological studies and as a reference standard in asymmetric synthesis and catalysis research.
• Material Science Precursor: Potential use in the development of organic electronic materials due to its extended conjugated system.

Basic Information

Product Name	(-)-3,4-Dihydro-3-Hydroxy-7-(5-Methoxy-2,2-Dimethyl-2H-1-Benzopyran-6-Yl)-2,2-Dimethyl-2H,6H-Benzo[1,2-B:5,4-B']Dipyran-6-One
CAS No.	481-94-7
Molecular Formula	C26H26O6
Molecular Weight	434.48 g/mol
Synonyms	(-)-Calanolide A; (-)-Costatolide; 11,12-Dihydro-12-hydroxy-6H,8H-dipyrano[2,3-f:2',3'-h]chromen-6-one, (12R)-; (12R)-12-Hydroxy-6H,8H-dipyrano[2,3-f:2',3'-h]chromen-6-one; NSC 675451; (+)-Calanolide A enantiomer; Anti-HIV-1 agent precursor; Benzopyranopyranone derivative.
EINECS	Contact for details

Quality Control

Our (-)-3,4-Dihydro-3-Hydroxy-7-(5-Methoxy-2,2-Dimethyl-2H-1-Benzopyran-6-Yl)-2,2-Dimethyl-2H,6H-Benzo[1,2-B:5,4-B']Dipyran-6-One is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with research and development grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.