Description

(1R)-1β,3α-Dimethyl-9-Methoxy-3,4,5,10-Tetrahydro-1H-Naphtho[2,3-C]Pyran-5,10-Dione is a high-purity, complex organic compound belonging to the naphthopyranone class, serving as a critical advanced intermediate in pharmaceutical synthesis. Its defined stereochemistry and functional groups make it a valuable building block for developing active pharmaceutical ingredients (APIs) with specific biological activity. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.
• Organic Synthesis Research: Used in academic and industrial R&D laboratories for studying cyclization reactions and constructing complex polycyclic frameworks.
• Process Chemistry Development: Serves as a standard or reference material for optimizing synthetic routes, yield, and purity in pilot-scale manufacturing.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals where a high degree of molecular specificity is required.

Basic Information

Product Name	(1R)-1β,3α-Dimethyl-9-Methoxy-3,4,5,10-Tetrahydro-1H-Naphtho[2,3-C]Pyran-5,10-Dione
CAS No.	478-37-5
Molecular Formula	C₁₆H₁₆O₄
Molecular Weight	272.30 g/mol
Synonyms	(1R)-1β,3α-Dimethyl-9-methoxy-3,4,5,10-tetrahydro-1H-naphtho[2,3-c]pyran-5,10-dione; 1H-Naphtho[2,3-c]pyran-5,10-dione, 3,4,5,10-tetrahydro-9-methoxy-1β,3α-dimethyl-, (1R)-; (R)-1β,3α-Dimethyl-9-methoxy-3,4,5,10-tetrahydro-1H-naphtho[2,3-c]pyran-5,10-dione; CAS 478-37-5
EINECS	Contact for details

Quality Control

Our (1R)-1β,3α-Dimethyl-9-Methoxy-3,4,5,10-Tetrahydro-1H-Naphtho[2,3-C]Pyran-5,10-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and specific test results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.