Description

5,6,7,8-Tetrahydro-8β-Hydroxy-7α-(Hydroxymethyl)-5β-(3,4,5-Trimethoxyphenyl)Naphtho[2,3-D]-1,3-Dioxole-6α-Carboxylic Acid is a complex, high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound, with CAS number 477-67-8, is valued for its intricate molecular architecture, which serves as a critical scaffold for the synthesis of novel therapeutic agents. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries working on innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-cancer drug candidates.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of target molecules in pilot plants and commercial manufacturing.
• Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in regulatory submissions.
• Academic & Institutional Research: Utilized in university and institutional labs for studying complex organic synthesis methodologies and reaction mechanisms.
• Bioconjugation & Prodrug Synthesis: Potential use in creating targeted drug delivery systems due to its functionalizable hydroxy and carboxylic acid groups.

Basic Information

Product Name	5,6,7,8-Tetrahydro-8β-Hydroxy-7α-(Hydroxymethyl)-5β-(3,4,5-Trimethoxyphenyl)Naphtho[2,3-D]-1,3-Dioxole-6α-Carboxylic Acid
CAS No.	477-67-8
Molecular Formula	C24H26O9
Molecular Weight	458.46 g/mol
Synonyms	Podophyllotoxin derivative; 6α-Carboxypodophyllotoxin; 6-Carboxypodophyllotoxin; 6-Carboxy-4'-demethylpodophyllotoxin; 6-Carboxy-4'-demethylepipodophyllotoxin; NSC 349156; 6α-Carboxy-4'-demethylpodophyllotoxin; 6-Carboxy-4'-demethyl-β-peltatin
EINECS	Contact for details

Quality Control

Our production of 5,6,7,8-Tetrahydro-8β-Hydroxy-7α-(Hydroxymethyl)-5β-(3,4,5-Trimethoxyphenyl)Naphtho[2,3-D]-1,3-Dioxole-6α-Carboxylic Acid adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0% Any single impurity ≤1.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.