Description

Chloromethyl Trifluoromethyl Sulfide is a specialized organosulfur compound featuring both chloromethyl and trifluoromethylthio functional groups. This unique structure makes it a valuable and versatile building block in advanced chemical synthesis, particularly for introducing the highly lipophilic and electron-withdrawing SCF3 moiety. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to develop novel compounds with enhanced metabolic stability and bioavailability. The product is supplied as a high-purity reagent to ensure optimal performance in sensitive applications.

Application

• Pharmaceutical Intermediate: A key synthon for the incorporation of the trifluoromethylthio group into active pharmaceutical ingredients (APIs), a moiety known to improve membrane permeability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the SCF3 group can enhance biological activity and environmental persistence.
• Material Science: Serves as a precursor for modifying polymer surfaces or creating novel monomers with specific fluorine-containing properties.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organocatalysts for asymmetric synthesis and cross-coupling reactions.
• Fluorine Chemistry Research: A critical reagent in academic and industrial R&D for exploring new methodologies in fluorine chemistry and organosulfur compound synthesis.

Basic Information

Product Name	Chloromethyl Trifluoromethyl Sulfide
CAS No.	460-58-2
Molecular Formula	C2H2ClF3S
Molecular Weight	150.55 g/mol
Synonyms	Trifluoromethyl Chloromethyl Sulfide; (Chloromethyl)(trifluoromethyl) Sulfane; Chloromethyl Trifluoromethyl Thioether; S-(Chloromethyl) Trifluoromethanethioate; α-Chloro-α'-trifluoromethyl Sulfide; 1-Chloro-2-(trifluoromethylthio)ethane (incorrect but common); CF3SCH2Cl
EINECS	Contact for details

Quality Control

Our Chloromethyl Trifluoromethyl Sulfide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production use. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Recommended storage temperature is 2-8°C to maximize stability. Keep container tightly sealed under an inert atmosphere to prevent moisture ingress and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.