Description

3-Bromobenzenesulfonyl Fluoride is a versatile organosulfur building block characterized by its reactive sulfonyl fluoride group and bromine substituent. This compound is essential for the synthesis of sulfonamide derivatives, which are key structural motifs in pharmaceuticals and agrochemicals. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that incorporate the sulfonamide pharmacophore.
• Chemical Biology & Proteomics: Serves as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent inhibitors due to the selectivity of the sulfonyl fluoride group.
• Material Science: Employed in the creation of specialty polymers and advanced materials where the introduction of sulfonamide linkages is required.
• Cross-Coupling Reactions: The bromine atom allows for further functionalization via palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig amination.
• Library Synthesis for Drug Discovery: A valuable building block for high-throughput and combinatorial chemistry to generate diverse compound libraries for screening.

Basic Information

Product Name	3-Bromobenzenesulfonyl Fluoride
CAS No.	454-65-9
Molecular Formula	C6H4BrFO2S
Molecular Weight	239.06 g/mol
Synonyms	m-Bromobenzenesulfonyl Fluoride; 3-Bromophenylsulfonyl Fluoride; Benzenesulfonyl fluoride, 3-bromo-; 1-Bromo-3-(fluorosulfonyl)benzene; 3-Bromobenzene-1-sulfonyl fluoride; m-Bromophenylsulfonyl fluoride; 454-65-9
EINECS	Contact for details

Quality Control

Our 3-Bromobenzenesulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.