Description

1-Chloro-3-Fluoro-Propan-2-One is a versatile halogenated ketone building block of significant interest in advanced organic synthesis. Its bifunctional reactive sites make it a critical intermediate for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro substitution pattern can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Precursor: Employed in the synthesis of monomers and cross-linking agents for specialty polymers with tailored properties.
• Fluorine Chemistry Research: A valuable reagent for introducing both chlorine and fluorine atoms in medicinal and process chemistry research programs.
• Custom Synthesis Building Block: Utilized by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule construction.

Basic Information

Product Name	1-Chloro-3-Fluoro-Propan-2-One
CAS No.	453-12-3
Molecular Formula	C3H4ClFO
Molecular Weight	110.51 g/mol
Synonyms	3-Chloro-1-fluoropropan-2-one; 1-Fluoro-3-chloropropan-2-one; 3-Chloro-1-fluoroacetone; 1-Chloro-3-fluoroacetone; Chlorofluoroacetone; Propan-2-one, 1-chloro-3-fluoro-; 2-Propanone, 1-chloro-3-fluoro-
EINECS	Contact for details

Quality Control

Our 1-Chloro-3-Fluoro-Propan-2-One is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its reactivity with strong bases and fluorides, keep away from incompatible materials. Containers should be kept tightly sealed when not in use to minimize moisture uptake and volatilization.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.