Description

2-Bromo-3-Fluorophenol is a halogenated phenol derivative that serves as a versatile and high-value synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both bromine and fluorine substituents, makes it a critical building block for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to develop new active ingredients and functional materials.

Application

The primary utility of 2-Bromo-3-Fluorophenol lies in its role as a key synthetic precursor. Its applications are centered around advanced research and manufacturing processes.

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Acts as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Chemistry: Employed to introduce halogenated phenolic units into polymer chains, modifying properties like flame retardancy, thermal stability, and solubility.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck), enabling the construction of complex biaryl structures.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic methodologies and creating specialized chemical libraries.

Basic Information

Product Name	2-Bromo-3-Fluorophenol
CAS No.	443-81-2
Molecular Formula	C6H4BrFO
Molecular Weight	191.00 g/mol
Synonyms	3-Fluoro-2-bromophenol; 2-Bromo-3-fluorophenol; Phenol, 2-bromo-3-fluoro-; o-Bromo-m-fluorophenol; 1-Bromo-2-fluoro-6-hydroxybenzene; 2-Bromo-3-fluoro-1-hydroxybenzene; (2-Bromo-3-fluorophenyl) alcohol
EINECS	207-149-7

Quality Control

We maintain a rigorous quality management system to ensure the consistency and purity of our 2-Bromo-3-Fluorophenol. Every batch is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be kept under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents, strong bases, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.