Description

1-Chloro-3,3,3-trifluoroacetone is a versatile fluorinated building block and reactive intermediate of significant industrial importance. Its unique structure, featuring both a reactive carbonyl and a chloro-trifluoromethyl group, makes it a critical precursor in the synthesis of complex fluorinated molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce trifluoromethyl motifs, which are known to enhance metabolic stability, lipophilicity, and bioavailability in final products.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing trifluoromethyl groups, particularly in antiviral and anticancer agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the CF3 group improves efficacy and environmental profile.
• Fluorinated Polymer & Material Science: Serves as a monomer or modifier in the creation of specialty polymers with enhanced chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: Acts as an electrophile in nucleophilic substitution reactions and as a precursor for other fluorinated ketones, acids, and heterocycles in fine chemical production.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated components for liquid crystal displays (LCDs) and dielectric materials.

Basic Information

Product Name	1-Chloro-3,3,3-trifluoroacetone
CAS No.	431-37-8
Molecular Formula	C3H2ClF3O
Molecular Weight	146.49 g/mol
Synonyms	3,3,3-Trifluoro-1-chloroacetone; 3,3,3-Trifluorochloracetone; 1-Chloro-3,3,3-trifluoro-2-propanone; Chlorotrifluoroacetone; TFCA; ω-Chloro-1,1,1-trifluoroacetone; 1-Chloro-1,1,1-trifluoroacetone (common misnomer); Acetone, 1-chloro-3,3,3-trifluoro-
EINECS	207-082-7

Quality Control

Our 1-Chloro-3,3,3-trifluoroacetone is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications, ensuring reliable supply and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, strong oxidizing agents, and strong reducing agents. Recommended storage temperature is 2-8°C to maximize stability. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.355 - 1.365
Density (20°C)	1.45 - 1.55 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.