Description

3-Bromo-1,1,1-trifluoroacetone is a versatile fluorinated building block characterized by its reactive bromine and trifluoromethyl ketone functionalities. This compound matters for its critical role in introducing the metabolically stable and lipophilic trifluoromethyl group into complex molecules, significantly altering their physical and biological properties. It is primarily needed by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for synthesizing advanced intermediates, active ingredients, and specialty materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and other bioactive molecules.
• Agrochemical Synthesis: Used in the production of advanced herbicides, pesticides, and fungicides where the CF3 group enhances efficacy and environmental stability.
• Material Science: Serves as a precursor for fluorinated polymers, coatings, and liquid crystals that require specific thermal and chemical resistance properties.
• Organic Synthesis Reagent: Employed in nucleophilic substitution and condensation reactions to incorporate the 1,1,1-trifluoroacetone moiety into more complex organic frameworks.
• Chemical Research & Development: A valuable tool for medicinal chemistry and discovery chemistry programs exploring structure-activity relationships (SAR) of fluorinated compounds.

Basic Information

Item	Detail
Product Name	3-Bromo-1,1,1-trifluoroacetone
CAS No.	431-35-6
Molecular Formula	C4H2BrF3O
Molecular Weight	190.96 g/mol
Synonyms	1-Bromo-3,3,3-trifluoroacetone; 3-Bromo-1,1,1-trifluoropropan-2-one; 3,3,3-Trifluoro-1-bromoacetone; 3-Bromotrifluoroacetone; Bromotrifluoroacetone; α-Bromo-α,α,α-trifluoroacetone; TFBA; BTFA
EINECS	207-081-7

Quality Control

Our 3-Bromo-1,1,1-trifluoroacetone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request, supporting your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.