Description

5-Chloroacetoxy-2-Benzyloxyisosorbide is a high-purity, specialized chemical intermediate derived from isosorbide. This compound matters for its role as a versatile building block in advanced organic synthesis, enabling the creation of complex molecules with precise stereochemistry. It is primarily needed by research and development teams in the pharmaceutical and fine chemical industries for applications such as polymer modification and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in cardiovascular and central nervous system (CNS) drug candidates.
• Polymer Chemistry: Serves as a functional monomer for synthesizing advanced biodegradable polymers and polyesters with tailored properties, leveraging the isosorbide backbone.
• Fine Chemical Synthesis: Used in multi-step organic synthesis to introduce protected hydroxyl and reactive chloroacetate functionalities for further derivatization.
• Academic & Industrial Research: A valuable reagent for methodological studies in asymmetric synthesis and catalysis within R&D laboratories.
• Material Science: Potential application in developing specialty coatings, adhesives, and resins where the benzyl and chloroacetoxy groups offer specific reactivity.

Basic Information

Product Name	5-Chloroacetoxy-2-Benzyloxyisosorbide
CAS No.	399534-53-3
Molecular Formula	C17H19ClO6
Molecular Weight	354.78 g/mol
Synonyms	1,4:3,6-Dianhydro-2-benzyloxy-5-chloroacetoxy-D-glucitol; 2-Benzyloxy-5-chloroacetoxyisosorbide; Isosorbide 2-benzyl ether 5-chloroacetate; 5-O-(Chloroacetyl)-2-O-benzylisosorbide; 2-O-Benzyl-5-O-chloroacetylisosorbide; 1,4:3,6-Dianhydro-2-O-benzyl-5-O-(chloroacetyl)-D-glucitol
EINECS	Contact for details

Quality Control

Our 5-Chloroacetoxy-2-Benzyloxyisosorbide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets exacting R&D and pilot-scale production standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.