Description

Androsta-1,4-Diene-17-Carbothioic Acid, 6,9-Difluoro-17-[(2-Furanylcarbonyl)Oxy]-16-Methyl-3,11-Dioxo-, S-(Fluoromethyl) Ester, (6α,16α,17α)- is a high-purity synthetic steroid derivative with a complex, multi-functional molecular structure. This compound is valued for its role as a critical advanced intermediate in pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing next-generation steroid-based treatments.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel glucocorticoid receptor modulators and other potent steroid-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new anti-inflammatory, immunosuppressive, or dermatological drugs with improved efficacy and safety profiles.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of complex steroid molecules in GMP or non-GMP environments.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis (HPLC, LC-MS).
• Biochemical Research: Utilized as a tool compound in preclinical studies to investigate steroid hormone receptor interactions and signaling pathways.

Basic Information

Product Name	Androsta-1,4-Diene-17-Carbothioic Acid, 6,9-Difluoro-17-[(2-Furanylcarbonyl)Oxy]-16-Methyl-3,11-Dioxo-, S-(Fluoromethyl) Ester, (6α,16α,17α)-
CAS No.	397864-56-1
Molecular Formula	C27H28F3O6S
Molecular Weight	537.57 g/mol
Synonyms	6α,9α-Difluoro-16α-methyl-3,11,20-trioxo-17α-[(2-furoyl)oxy]-1,4-pregnadiene-17β-carbothioic acid S-(fluoromethyl) ester; Difluoromethylprednisolone furoate 17β-carbothioic acid S-fluoromethyl ester; (6α,16α,17α)-6,9-Difluoro-16-methyl-3,11-dioxo-17-[(2-furanylcarbonyl)oxy]androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester; A fluorinated steroid thioester intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development projects requiring material aligned with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.