Description

2-[2-(2-{2-[2-(tert-Butyl-Dimethyl-Silanyloxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethanol is a specialized polyethylene glycol (PEG) derivative featuring a terminal tert-butyldimethylsilyl (TBDMS) protecting group. This compound is engineered to provide controlled reactivity and enhanced stability in advanced synthetic processes, serving as a crucial building block for creating complex molecular architectures. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as polymer synthesis, bioconjugation, and the development of drug delivery systems.

Application

• Pharmaceutical Intermediates: Acts as a key synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for introducing hydrophilic PEG spacers.
• Polymer & Dendrimer Synthesis: Serves as a versatile monomer or initiator for creating functionalized polymers, dendrimers, and star-shaped macromolecules with precise chain lengths.
• Bioconjugation & Linker Chemistry: Used to modify peptides, proteins, and oligonucleotides, facilitating the attachment of drugs, dyes, or other functional molecules via its reactive hydroxyl group after deprotection.
• Surface Modification & Functionalization: Applied to modify the surface properties of nanoparticles, quantum dots, and other nanomaterials to improve solubility, biocompatibility, and targeting.
• Protecting Group Strategy: The TBDMS group protects the terminal alcohol during synthetic sequences, allowing for selective reactions at other sites on the molecule.
• Hydrogel & Biomaterial Fabrication: Incorporated as a cross-linking agent or hydrophilic component in the development of hydrogels for medical and diagnostic applications.

Basic Information

Product Name	2-[2-(2-{2-[2-(tert-Butyl-Dimethyl-Silanyloxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethanol
CAS No.	393174-68-0
Molecular Formula	C18H40O7Si
Molecular Weight	396.60 g/mol
Synonyms	TBDMS-PEG5-OH; tert-Butyldimethylsilyl-PEG5-alcohol; 2,5,8,11,14-Pentaoxa-17-silaheptadecan-17-ol, 17-(1,1-dimethylethyl)-17-methyl-; TBDMS-protected pentaethylene glycol; Monofunctional TBDMS-PEG (n=5); TBDMS-O-(CH2CH2O)5-H; Poly(ethylene glycol) monomethyl ether TBDMS ether (MW ~400)
EINECS	Contact for details

Quality Control

Our 2-[2-(2-{2-[2-(tert-Butyl-Dimethyl-Silanyloxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethanol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain optimal quality.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.