Description

1-Pyrenylmethyl Methanethiosulfonate is a specialized chemical reagent featuring a pyrene fluorophore linked to a methanethiosulfonate (MTS) reactive group. This compound is critical for site-directed spin labeling (SDSL) and fluorescence studies in structural biology and biophysics. It is primarily used by researchers and manufacturers in the life sciences sector for probing protein structure, dynamics, and conformational changes. The reagent enables the covalent attachment of spectroscopic probes to specific cysteine residues within biomolecules.

Application

• Site-Directed Spin Labeling (SDSL): A key reagent for introducing spin labels onto cysteine residues of proteins for Electron Paramagnetic Resonance (EPR) spectroscopy.
• Fluorescence Labeling & Spectroscopy: Used to attach the pyrene fluorophore to biomolecules for studying protein folding, interactions, and conformational dynamics via fluorescence quenching or anisotropy.
• Structural Biology Research: Essential tool for mapping solvent accessibility, measuring distances, and determining topological constraints in membrane and soluble proteins.
• Bioconjugation & Probe Development: Serves as a building block for creating advanced diagnostic or research probes that require a specific, thiol-reactive linkage.
• Pharmaceutical R&D: Utilized in early-stage drug discovery to investigate target protein-ligand interactions and mechanisms of action.

Basic Information

Product Name	1-Pyrenylmethyl Methanethiosulfonate
CAS No.	384342-65-8
Molecular Formula	C18H14O2S2
Molecular Weight	326.43 g/mol
Synonyms	PMTS; Pyrene MTS; 1-Pyrenemethyl methanethiosulfonate; (Pyren-1-ylmethyl) methanesulfonothioate; Methanesulfonothioic acid S-[(pyren-1-yl)methyl] ester; 1-Pyrenylmethyl methanesulfonothioate; Pyren-1-ylmethyl methanethiosulfonate; 1-(Methanethiosulfonylmethyl)pyrene
EINECS	Contact for details

Quality Control

Our 1-Pyrenylmethyl Methanethiosulfonate is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized by HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The compound is moisture-sensitive and should be handled under dry conditions. Allow the vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.