Description

(2R,3R)-2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)Morpholine CAS NO 380499-06-9 is a high-purity, chiral morpholine derivative of significant importance in advanced pharmaceutical synthesis. This compound serves as a critical intermediate or building block for the development of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, especially in neuropharmacology.
• API Synthesis: Used in research-scale and process chemistry for constructing the core scaffold of potential new medicines.
• Asymmetric Catalysis Research: Serves as a ligand precursor or a model compound in the study of stereoselective reactions.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.
• Process Development: Critical for scaling up synthetic routes from laboratory to pilot plant and commercial production.

Basic Information

Product Name	(2R,3R)-2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)Morpholine
CAS No.	380499-06-9
Molecular Formula	C21H18F7NO2
Molecular Weight	449.36 g/mol
Synonyms	(2R,3R)-2-[(1R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)morpholine; (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinemethanol (tautomer); Aprepitant Intermediate Derivative; Chiral Trifluoromethyl Phenyl Morpholine; 4-Fluorophenyl Morpholine Derivative; Neurokinin-1 (NK1) Receptor Antagonist Intermediate; CAS 380499-06-9
EINECS	Contact for details

Quality Control

Our (2R,3R)-2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)Morpholine is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be sensitive to strong alkali. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.