Description

1,1-Dichloro-1A-(4-Ethoxyphenyl)-7-(4-Fluorophenyl)-1,1A,7,7A-Tetrahydrocyclopropa[B]Chromene is a high-purity, complex organic intermediate featuring a unique cyclopropa[b]chromene core structure. This compound is valued for its role as a critical building block in advanced pharmaceutical synthesis and materials science research. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders or with complex polycyclic frameworks.
• Agrochemical Research: Serves as a sophisticated scaffold for developing new-generation herbicides or fungicides with enhanced activity and selectivity.
• Material Science: Potential monomer or precursor for advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters or charge transport materials, due to its extended conjugated system.
• Chemical Biology Probe Development: Used to create tool compounds for studying biological pathways and protein-ligand interactions in academic and industrial research settings.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization studies for the commercial production of high-value fine chemicals.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this specialized intermediate.

Basic Information

Product Name	1,1-Dichloro-1A-(4-Ethoxyphenyl)-7-(4-Fluorophenyl)-1,1A,7,7A-Tetrahydrocyclopropa[B]Chromene
CAS No.	374566-06-0
Molecular Formula	C26H21Cl2FO2
Molecular Weight	455.35 g/mol
Synonyms	1,1-Dichloro-1a-(4-ethoxyphenyl)-7-(4-fluorophenyl)-1,1a,7,7a-tetrahydrocyclopropa[b]chromene; 1a-(4-Ethoxyphenyl)-7-(4-fluorophenyl)-1,1-dichloro-1,1a,7,7a-tetrahydrocyclopropa[b]chromene; Cyclopropa[b]chromene, 1,1-dichloro-1a-(4-ethoxyphenyl)-7-(4-fluorophenyl)-1,1a,7,7a-tetrahydro-; CAS 374566-06-0; 374566-06-0; 1,1-Dichloro-1a-(p-ethoxyphenyl)-7-(p-fluorophenyl)-1,1a,7,7a-tetrahydrocyclopropa[b]chromene
EINECS	Contact for details

Quality Control

Our 1,1-Dichloro-1A-(4-Ethoxyphenyl)-7-(4-Fluorophenyl)-1,1A,7,7A-Tetrahydrocyclopropa[B]Chromene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO compliant production for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.