Description

(1S,2R)-Methyl 2-Aminocyclohexanecarboxylate Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. This compound is valued for its defined stereochemistry, which is critical for synthesizing enantiomerically pure active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas requiring sophisticated chiral synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, including potential candidates for central nervous system (CNS) and antiviral therapies.
• Asymmetric Synthesis: Utilized as a precursor or auxiliary in catalytic asymmetric reactions to construct stereogenic centers with high enantiomeric excess.
• Peptidomimetics Research: Serves as a constrained, cyclic amino acid analog for the design and synthesis of novel peptide-like compounds with enhanced metabolic stability.
• Agrochemical Development: Employed in the research phase for creating chiral active ingredients in advanced crop protection agents.
• Academic & Process Chemistry: Used in methodological development and scale-up studies for new synthetic routes in academic and industrial R&D laboratories.
• Custom Synthesis: A starting material for contract manufacturing of specialized, customer-specific chiral compounds.

Basic Information

Product Name	(1S,2R)-Methyl 2-Aminocyclohexanecarboxylate Hydrochloride
CAS No.	362490-42-4
Molecular Formula	C8H16ClNO2
Molecular Weight	193.67 g/mol
Synonyms	Methyl (1S,2R)-2-aminocyclohexanecarboxylate hydrochloride; (1S,2R)-2-Aminocyclohexanecarboxylic acid methyl ester hydrochloride; trans-Methyl 2-aminocyclohexanecarboxylate HCl; Methyl L-trans-2-aminocyclohexanecarboxylate hydrochloride; Methyl trans-2-aminocyclohexanecarboxylate hydrochloride; (1S,2R)-Methyl 2-aminocyclohexanecarboxylate HCl; Cyclohexanecarboxylic acid, 2-amino-, methyl ester, hydrochloride, (1S,2R)-
EINECS	Contact for details

Quality Control

Our (1S,2R)-Methyl 2-Aminocyclohexanecarboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods for identity and assay, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, chiral excess, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.