Description

6-Amino-4-(2,5-Dimethoxyphenyl)-1,4-Dihydro-3-(2-Naphthalenyl)-Pyrano[2,3-C]Pyrazole-5-Carbonitrile is a high-purity, advanced pharmaceutical intermediate belonging to the pyranopyrazole class of heterocyclic compounds. Its complex molecular architecture makes it a critical building block for the research and development of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors. Its structural features are leveraged in medicinal chemistry programs targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the multi-step synthesis of potential drug candidates, particularly in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of new chemical entities.
• Organic Synthesis Building Block: Employed in complex organic transformations to construct fused heterocyclic systems due to its reactive amino and nitrile functional groups.
• Biochemical Tool Compound: May be utilized in vitro to study specific biological pathways or enzyme interactions as part of early-stage drug discovery.
• Contract Research & Manufacturing (CRMO): Supplied to organizations specializing in custom synthesis and scale-up of complex molecules for clinical trials.

Basic Information

Item	Detail
Product Name	6-Amino-4-(2,5-Dimethoxyphenyl)-1,4-Dihydro-3-(2-Naphthalenyl)-Pyrano[2,3-C]Pyrazole-5-Carbonitrile
CAS No.	361185-42-4
Molecular Formula	C25H20N4O3
Molecular Weight	424.46 g/mol
Synonyms	6-Amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(naphthalen-2-yl)pyrano[2,3-c]pyrazole-5-carbonitrile; 6-Amino-3-(2-naphthyl)-4-(2,5-dimethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile; Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-4-(2,5-dimethoxyphenyl)-1,4-dihydro-3-(2-naphthalenyl)-; 361185-42-4; AI-285/43438051; AK-781/43438051; ZINC000003869756
EINECS	Contact for details

Quality Control

Our 6-Amino-4-(2,5-Dimethoxyphenyl)-1,4-Dihydro-3-(2-Naphthalenyl)-Pyrano[2,3-C]Pyrazole-5-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP guidelines for early-phase development. Specifications are aligned with industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.