Description

1,2-Benzenedimethanol,-α-,-α--Diethyl-,(-α-S,-α-S)-(9Ci) is a chiral, non-racemic organic compound featuring a 1,2-benzenedimethanol core with diethyl substitutions at the alpha positions. This specific stereochemistry makes it a valuable chiral building block and intermediate in advanced organic synthesis. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and fine chemical industries for the production of enantiomerically pure active pharmaceutical ingredients (APIs), ligands, and other complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of potential drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Ligand Synthesis: Used in the preparation of chiral ligands for asymmetric catalysis, such as phosphines and N,P-ligands, which are critical for enantioselective hydrogenation and cross-coupling reactions.
• Fine Chemical Production: Serves as a precursor for the manufacture of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Material Science Research: Investigated as a monomer or cross-linking agent for the development of novel chiral polymers and advanced organic materials.
• Academic & Industrial R&D: Employed in method development and discovery chemistry for exploring new synthetic pathways and reaction mechanisms.

Basic Information

Product Name	1,2-Benzenedimethanol,-α-,-α--Diethyl-,(-α-S,-α-S)-(9Ci)
CAS No.	357427-66-8
Molecular Formula	C14H22O2
Molecular Weight	222.32 g/mol
Synonyms	(1S,2S)-1,2-Bis(1-hydroxypropyl)benzene; (S,S)-1,2-Bis(1-hydroxypropyl)benzene; (1S,2S)-1,2-Diethyl-1,2-benzenedimethanol; 1,2-Benzenedimethanol, α,α'-diethyl-, (αS,α'S)-; (S,S)-H8-BINOL derivative; Chiral diol C14; 1,2-Bis(α-hydroxypropyl)benzene (S,S-isomer)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical enantiomeric excess (e.e.) of >98% as determined by chiral HPLC analysis. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and identification data. Our quality management system supports cGMP and ISO standards for traceability and consistency, making this material suitable for demanding pharmaceutical R&D and pilot-scale applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere (argon or nitrogen) to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.