Description

2H-Pyran-3-Methanol,4-Fluorotetrahydro-6-Methyl-,(3R,4R,6S)-Rel-(9Ci) CAS NO 351875-55-3 is a high-purity, stereochemically defined fluorinated pyran derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a structurally complex, fluorinated scaffold essential for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where the introduction of fluorine enhances stability and bioactivity.
• Chemical Biology Probe Development: Serves as a foundational structure for creating molecular probes to study enzyme mechanisms and biological pathways.
• Material Science Research: Employed in the synthesis of novel fluorinated polymers or liquid crystals with unique electronic or optical properties.
• Process Chemistry & Scale-Up: Provides a defined starting point for optimizing synthetic routes and developing cost-effective manufacturing processes for complex molecules.

Basic Information

Product Name	2H-Pyran-3-Methanol,4-Fluorotetrahydro-6-Methyl-,(3R,4R,6S)-Rel-(9Ci)
CAS No.	351875-55-3
Molecular Formula	C7H13FO2
Molecular Weight	148.18 g/mol
Synonyms	(3R,4R,6S)-4-Fluoro-6-methyltetrahydro-2H-pyran-3-methanol; rel-(3R,4R,6S)-4-Fluoro-6-methyltetrahydro-2H-pyran-3-methanol; 4-Fluoro-6-methyltetrahydro-2H-pyran-3-methanol (rel-(3R,4R,6S)-); Fluorinated Tetrahydro-2H-pyran-3-methanol derivative; Chiral Fluoropyran Building Block; CAS 351875-55-3
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management protocols. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, typically including HPLC purity (≥98%), chiral purity analysis, and structural confirmation via NMR and MS. A detailed Certificate of Analysis (COA) is supplied with each shipment, and custom purity grades or analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). For long-term storage, consider keeping the material under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.