Description

6,7-Diethoxy-4-(Trifluoromethyl)Coumarin is a high-purity fluorinated coumarin derivative, a key advanced intermediate in organic synthesis. Its value lies in its unique trifluoromethyl-substituted coumarin scaffold, which is crucial for developing compounds with enhanced biological activity and photophysical properties. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries, particularly for applications in medicinal chemistry, fluorescent probes, and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, especially in the development of enzyme inhibitors, receptor antagonists, and other bioactive molecules leveraging the trifluoromethyl group for improved metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the coumarin core and fluorine atoms contribute to potent biological activity and environmental persistence.
• Fluorescent Dye & Probe Precursor: Serves as a key starting material for creating specialized fluorescent tags, sensors, and imaging agents used in biochemical assays, diagnostics, and cellular imaging due to its modifiable coumarin structure.
• Organic Electronic Materials: Employed in the development of organic light-emitting diodes (OLEDs), photovoltaic cells, and other optoelectronic devices where its electron-deficient trifluoromethyl group and conjugated system are advantageous.
• Chemical Research & Development: A versatile scaffold for academic and industrial R&D focused on exploring new chemical spaces, structure-activity relationships (SAR), and novel synthetic methodologies.

Basic Information

Product Name	6,7-Diethoxy-4-(Trifluoromethyl)Coumarin
CAS No.	351002-66-9
Molecular Formula	C₁₄H₁₃F₃O₄
Molecular Weight	302.25 g/mol
Synonyms	4-(Trifluoromethyl)-6,7-diethoxycoumarin; 6,7-Diethoxy-4-trifluoromethylcoumarin; 2H-1-Benzopyran-2-one, 6,7-diethoxy-4-(trifluoromethyl)-; 4-Trifluoromethyl-6,7-diethoxycoumarin; 6,7-Diethoxy-4-(trifluoromethyl)-2H-chromen-2-one; Coumarin 152A (related dye analog); C₆H₅(OC₂H₅)₂C₉H₄O₂CF₃ (obsolete formula representation)
EINECS	Contact for details

Quality Control

Our 6,7-Diethoxy-4-(Trifluoromethyl)Coumarin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced intermediate applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.