Description

1-Chloro-2-(Chloromethyl)-3-Methoxybenzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. Its bifunctional structure, featuring both a reactive chloromethyl group and a chloro substituent on a methoxybenzene scaffold, makes it a valuable precursor for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key starting material (KSM) or advanced intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those with complex aromatic or heterocyclic structures.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides, leveraging its halogenated aromatic core.
• Ligand and Catalyst Development: Precursor for synthesizing specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Monomer or functionalization agent in the development of specialty polymers, liquid crystals, or organic electronic materials.
• Custom Synthesis and Contract Manufacturing: Serves as a critical raw material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic and R&D Laboratories: Used in methodological research and for exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	1-Chloro-2-(Chloromethyl)-3-Methoxybenzene
CAS No.	344294-26-4
Molecular Formula	C8H8Cl2O
Molecular Weight	191.05 g/mol
Synonyms	2-Chloromethyl-6-chloroanisole; 3-Methoxy-2-chloromethylchlorobenzene; 1-Chloro-2-(chloromethyl)-3-methoxybenzene; 2-Chloro-6-(chloromethyl)anisole; 6-Chloro-2-(chloromethyl)anisole; Benzene, 1-chloro-2-(chloromethyl)-3-methoxy-; (2-Chloro-6-methoxyphenyl)methyl chloride
EINECS	Contact for details

Quality Control

Every batch of 1-Chloro-2-(Chloromethyl)-3-Methoxybenzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. A detailed Certificate of Analysis (COA), including purity assay and impurity profile determined by techniques such as GC/HPLC, is supplied with each shipment to guarantee traceability, consistency, and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC/GC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.