Description

4-Hydroxy-Isoxazolidine-2-Carboxylic Acid Cyclohexylamide is a specialized heterocyclic amide derivative of significant interest in advanced organic synthesis. This compound matters as a versatile chiral building block and intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in medicinal chemistry and catalyst design.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for compounds targeting neurological and metabolic disorders.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its unique isoxazolidine scaffold.
• Ligand and Catalyst Precursor: Acts as a precursor for chiral ligands used in asymmetric catalysis, such as hydrogenation and cross-coupling reactions.
• Peptidomimetics and Bioisosteres: The structural motif is valuable for designing peptide mimics and bioisosteres in drug discovery programs.
• Academic and Institutional R&D: Employed in universities and research institutes for methodological studies in heterocyclic and amide chemistry.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for producing high-value, low-volume specialty chemicals.

Basic Information

Product Name	4-Hydroxy-Isoxazolidine-2-Carboxylic Acid Cyclohexylamide
CAS No.	344276-21-7
Molecular Formula	C10H18N2O3
Molecular Weight	214.26 g/mol
Synonyms	Cyclohexylamide of 4-Hydroxyisoxazolidine-2-carboxylic Acid; 4-Hydroxy-2-(cyclohexylcarbamoyl)isoxazolidine; 4-Hydroxyisoxazolidine-2-carboxamide, N-cyclohexyl-; 2-Isoxazolidinecarboxylic acid, 4-hydroxy-, cyclohexylamide; 4-Hydroxyisoxazolidine-2-carboxylic acid cyclohexyl amide; N-Cyclohexyl-4-hydroxyisoxazolidine-2-carboxamide
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-Isoxazolidine-2-Carboxylic Acid Cyclohexylamide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.