Description

(S)-Boc-3-Amino-2-(Phenylsulfonylamino)-Propionic Acid CAS NO 342888-28-2 is a high-purity, non-natural amino acid derivative featuring both Boc (tert-butoxycarbonyl) and phenylsulfonyl protecting groups. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, enabling precise control over stereochemistry and molecular architecture. It is primarily utilized by pharmaceutical R&D and process chemistry teams for developing novel therapeutic agents, including protease inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease-targeted therapies.
• Peptide Synthesis: Serves as a specialized, protected amino acid residue for solid-phase and solution-phase peptide synthesis, allowing for the introduction of unique sulfonamide functionalities.
• Peptidomimetic Design: Essential for constructing peptidomimetic scaffolds in drug discovery programs aiming to improve metabolic stability and bioavailability over natural peptides.
• Chemical Biology Probes: Used in the synthesis of labeled or modified peptides for studying enzyme mechanisms, protein-protein interactions, and cellular pathways.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for candidate drugs during clinical development phases.

Basic Information

Product Name	(S)-Boc-3-Amino-2-(Phenylsulfonylamino)-Propionic Acid
CAS No.	342888-28-2
Molecular Formula	C14H20N2O6S
Molecular Weight	344.38 g/mol
Synonyms	(S)-2-[(tert-Butoxycarbonyl)amino]-3-[(phenylsulfonyl)amino]propanoic acid; N-Boc-N'-tosyl-L-diaminopropionic acid (common abbreviation); Boc-Asn(Ts)-OH (common peptide notation); tert-Butyl (S)-(1-((phenylsulfonyl)amino)-3-carboxy-1-oxopropan-2-yl)carbamate; (S)-3-Amino-2-(phenylsulfonylamino)-propionic acid tert-butyl ester; Boc-L-2,3-diaminopropionic acid(Tos); Nα-Boc-Nβ-(phenylsulfonyl)-L-2,3-diaminopropionic acid
EINECS	Contact for details

Quality Control

Our (S)-Boc-3-Amino-2-(Phenylsulfonylamino)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.