Description

2-(Difluoromethoxy)Benzohydrazide is a specialized aromatic hydrazide derivative featuring a difluoromethoxy substituent, offering unique reactivity and physicochemical properties. This compound serves as a valuable pharmaceutical intermediate and organic synthesis building block, enabling the construction of complex molecules for research and development. It is primarily utilized by pharmaceutical R&D teams, agrochemical manufacturers, and fine chemical synthesis specialists seeking to incorporate its distinct fluorinated moiety.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the difluoromethoxy group can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a versatile building block for creating chelating ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the synthesis of monomers and polymers with specific optical or electronic properties for advanced material applications.
• Chemical Biology Probes: Utilized as a scaffold for developing fluorescent tags, enzyme inhibitors, and other molecular probes for biochemical research.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up production under cGMP or ISO standards for client-specific molecules.

Basic Information

Product Name	2-(Difluoromethoxy)Benzohydrazide
CAS No.	333430-83-4
Molecular Formula	C8H8F2N2O2
Molecular Weight	202.16 g/mol
Synonyms	2-(Difluoromethoxy)benzohydrazide; Benzohydrazide, 2-(difluoromethoxy)-; o-(Difluoromethoxy)benzohydrazide; 2-(Difluoromethoxy)benzoic acid hydrazide; 333430-83-4; DFMBH; Salicylaldehyde difluoromethyl ether hydrazone (precursor-related)
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Benzohydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure compliance with exacting specifications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for every shipment. We support development and commercial projects requiring material traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its nature as an easily oxidized compound, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.