Description

4,4-Diethoxy-1,1,1-trifluoro-2-butanone is a specialized fluorinated organic building block with the CAS number 333339-64-3. This compound is valued for its unique trifluoromethyl ketone moiety protected by diethyl acetal groups, making it a versatile intermediate for introducing fluorine into complex molecular architectures. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the trifluoromethyl group can significantly enhance metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of trifluoromethyl-containing drug candidates, including protease inhibitors, kinase inhibitors, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the CF3 group improves efficacy and environmental persistence.
• Material Science Precursor: Serves as a building block for fluorinated polymers, liquid crystals, and specialty coatings that require specific thermal and chemical resistance properties.
• Organic Synthesis Reagent: Employed in academic and industrial research for constructing complex fluorinated molecules via nucleophilic addition, condensation, or cross-coupling reactions.
• Fluorine Chemistry Research: An essential tool for studying the effects of fluorine substitution on chemical reactivity and physical properties in new compound libraries.

Basic Information

Product Name	4,4-Diethoxy-1,1,1-trifluoro-2-butanone
CAS No.	333339-64-3
Molecular Formula	C8H13F3O3
Molecular Weight	214.18 g/mol
Synonyms	1,1,1-Trifluoro-4,4-diethoxy-2-butanone; 4,4-Diethoxy-1,1,1-trifluorobutan-2-one; 1,1,1-Trifluoro-2-butanone, 4,4-diethoxy-; Ethyl 2,2-diethoxy-4,4,4-trifluoroacetoacetate (common misnomer); TFBA diethyl acetal; Trifluoroacetoacetic acid diethyl acetal ketone; 4,4-Diethoxy-1,1,1-trifluoro-butane-2-one
EINECS	Contact for details

Quality Control

Our 4,4-Diethoxy-1,1,1-trifluoro-2-butanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay and impurity profiles. Our quality commitment supports applications requiring high-purity intermediates for GLP and cGMP-compliant research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature and sensitivity to fluoride/strong alkali conditions, keep away from heat, sparks, and incompatible materials. For long-term storage, consider using sealed containers under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.