Description

Methylglyoxal Bis-(Guanylhydrazone)*Dihy Drochloride CAS NO 332360-02-8 is a high-purity chemical compound of significant interest in advanced biochemical research and pharmaceutical development. This compound matters for its role as a specific inhibitor of S-adenosylmethionine decarboxylase, a key enzyme in polyamine biosynthesis, making it a valuable tool for studying cellular proliferation and differentiation. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on oncology, parasitology, and metabolic pathway analysis.

Application

• Biochemical Research: Used as a potent and selective inhibitor of S-adenosylmethionine decarboxylase (AdoMetDC) to study polyamine metabolism and its role in cell growth.
• Oncology Research: Investigated for its potential antiproliferative effects in various cancer cell line studies due to its ability to deplete intracellular polyamines.
• Parasitology Studies: Applied in research targeting tropical diseases, as polyamine biosynthesis is a critical pathway for the survival of certain parasites like trypanosomes.
• Pharmaceutical Intermediate: Serves as a key synthetic intermediate or reference standard in the development of novel therapeutic agents.
• Enzyme Kinetics: Utilized in enzymatic assays to determine kinetic parameters and inhibition constants (Ki) for AdoMetDC.
• Cell Culture & Molecular Biology: Employed in *in vitro* experiments to modulate polyamine levels and observe downstream effects on gene expression and apoptosis.

Basic Information

Product Name	Methylglyoxal Bis-(Guanylhydrazone)*Dihy Drochloride
CAS No.	332360-02-8
Molecular Formula	C6H16Cl2N8O2 • xH2O
Molecular Weight	Contact for details
Synonyms	MGBG Dihydrochloride; Methyl-GAG Dihydrochloride; Mitoguazone Dihydrochloride; Methylglyoxal Bis(guanylhydrazone) Dihydrochloride; 1,1'-[(Methylethanediylidene)dinitrilo]diguanidine Dihydrochloride; NSC-32946 Dihydrochloride; MGBC Dihydrochloride; AdoMetDC Inhibitor
EINECS	Contact for details

Quality Control

Our Methylglyoxal Bis-(Guanylhydrazone) Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and heavy metals to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with complete batch data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.