Description

Ac-D-Ala(Cl)-Ome is a protected amino acid derivative, specifically an N-acetylated D-alanine methyl ester with a chloro-substituted side chain. This compound serves as a crucial chiral building block and intermediate in advanced organic synthesis, offering precise stereochemical control. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex peptide-based drugs and therapeutic agents.
• Peptide Chemistry Research: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce D-alanine residues with specific protecting groups.
• Protease Inhibitor Development: Acts as a precursor or core structure in the design of enzyme inhibitors targeting specific proteolytic pathways.
• Chemical Biology Probes: Employed in the creation of labeled or modified peptides for studying protein-protein interactions and cellular processes.
• Chiral Auxiliary/Synthon: Provides a stereochemically defined scaffold for asymmetric synthesis in medicinal chemistry.

Basic Information

Product Name	Ac-D-Ala(Cl)-Ome
CAS No.	327064-63-1
Molecular Formula	C6H10ClNO3
Molecular Weight	179.60 g/mol
Synonyms	N-Acetyl-D-3-chloroalanine methyl ester; Methyl N-acetyl-3-chloro-D-alaninate; Ac-D-3-Cl-Ala-OMe; (R)-Methyl 2-acetamido-3-chloropropanoate; D-3-Chloro-N-acetylalanine methyl ester; N-Acetyl-D-β-chloroalanine methyl ester
EINECS	Contact for details

Quality Control

Our Ac-D-Ala(Cl)-Ome is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.