Description

(Trifluoromethyl)Tris(Triphenylphosphine)Copper(I) CAS NO 325810-07-9 is a highly specialized organocopper reagent, a key source of the nucleophilic trifluoromethyl anion (CF3⁻) equivalent. This compound matters for its unique ability to facilitate the efficient and selective introduction of the trifluoromethyl group into organic molecules, a transformation of paramount importance in modern synthetic chemistry. It is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel fluorinated compounds with enhanced properties.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for the late-stage trifluoromethylation of drug candidates to improve metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Development: Used in the synthesis of novel fluorinated pesticides and herbicides, where the CF3 group can enhance biological activity and environmental persistence.
• Ligand & Catalyst Research: Serves as a precursor or model compound in the study of copper(I) phosphine complexes and their catalytic behavior.
• Organic Electronics & Materials Science: Enables the synthesis of fluorinated π-conjugated systems for use in OLEDs, semiconductors, and specialty polymers.
• Nucleophilic Trifluoromethylation: Employed in reactions with a wide range of electrophiles, including carbonyl compounds, alkyl/aryl halides, and epoxides.
• Cross-Coupling Reactions: Participates in copper-mediated coupling processes to form new carbon-carbon bonds bearing the CF3 moiety.

Basic Information

Product Name	(Trifluoromethyl)Tris(Triphenylphosphine)Copper(I)
CAS No.	325810-07-9
Molecular Formula	C55H45CuF3P3
Molecular Weight	907.42 g/mol
Synonyms	Copper, (trifluoromethyl)tris(triphenylphosphine)-; Trifluoromethyltris(triphenylphosphine)copper(I); (Trifluoromethyl)triphenylphosphine copper(I) complex; CF3Cu(PPh3)3; Trifluoromethylcopper(I) triphenylphosphine complex; Tris(triphenylphosphine)(trifluoromethyl)copper; Nucleophilic trifluoromethylation reagent
EINECS	Contact for details

Quality Control

Every batch of (Trifluoromethyl)Tris(Triphenylphosphine)Copper(I) is manufactured and handled under strict inert atmosphere conditions to ensure product integrity. Our products undergo rigorous quality testing, including NMR and elemental analysis, to ensure compliance with high-purity reagent standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry place. This material is easily oxidized and hygroscopic (moisture-sensitive); prolonged exposure to air or moisture must be avoided to maintain reactivity and purity.

Specification

Item	Specification
Appearance	Off-white to beige powder or crystals
Identification (NMR)	Conforms to structure
Purity (NMR / Elemental Analysis)	≥95%
Moisture Content (KF)	≤1.0%
Solubility	Soluble in common organic solvents (THF, DCM, toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.