Description

1-Bromomethyl-2,4-Difluoro-5-Methyl-Benzene is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. Its molecular structure, featuring both bromomethyl and difluoro substituents, makes it a versatile intermediate for introducing specific functional groups and modifying electronic properties in target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides, where the difluoromethylbenzene moiety can improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic cores in electronic materials, contributing to desired dielectric and luminescent properties.
• Cross-Coupling Reactions: The bromomethyl group is an effective handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Functional Polymer Monomer: Can be incorporated into polymer backbones to create materials with specific solubility, thermal stability, or chemical resistance characteristics.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development and exploring new synthetic pathways involving halogenated fluorobenzenes.

Basic Information

Product Name	1-Bromomethyl-2,4-Difluoro-5-Methyl-Benzene
CAS No.	315204-37-6
Molecular Formula	C8H7BrF2
Molecular Weight	221.04 g/mol
Synonyms	2,4-Difluoro-5-methylbenzyl bromide; (2,4-Difluoro-5-methylphenyl)methyl bromide; 5-Methyl-2,4-difluorobenzyl bromide; α-Bromo-2,4-difluoro-5-methyltoluene; 1-(Bromomethyl)-2,4-difluoro-5-methylbenzene; Benzene, 1-(bromomethyl)-2,4-difluoro-5-methyl-; 2,4-Difluoro-α-bromo-5-methyltoluene
EINECS	Contact for details

Quality Control

Our 1-Bromomethyl-2,4-Difluoro-5-Methyl-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed batch-specific results are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The compound is moisture-sensitive; containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.