Description

1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-Tetraacetic Acid Tetrahydrochloride Hydrate is a high-purity, functionalized macrocyclic chelating agent, essential for the synthesis of advanced metal complexes. Its core value lies in its exceptional ability to form highly stable and kinetically inert complexes with a range of metal ions, particularly lanthanides and transition metals. This product is critically needed by researchers and manufacturers in the pharmaceutical, diagnostic imaging, and advanced materials sectors for developing next-generation contrast agents, radiopharmaceuticals, and catalysts.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing MRI contrast agents (e.g., Gadolinium-based complexes) and therapeutic radiopharmaceuticals.
• Diagnostic Imaging: Chelation platform for radiolabeling (e.g., with 64Cu, 68Ga, 177Lu) for PET and SPECT imaging probes.
• Research & Development: Fundamental building block in coordination chemistry for studying metal-ligand interactions and developing novel metal-organic frameworks (MOFs).
• Catalysis: Ligand for creating homogeneous catalysts used in organic synthesis and industrial chemical processes.
• Analytical Chemistry: Used as a complexing agent in chelation titrations and for the selective separation and detection of metal ions.
• Material Science: Incorporation into functional materials for sensing, luminescence, and data storage applications.

Basic Information

Product Name	1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-Tetraacetic Acid Tetrahydrochloride Hydrate
CAS No.	314041-07-1
Molecular Formula	C18H34Cl4N4O8 • xH2O
Molecular Weight	566.20 (anhydrous basis)
Synonyms	DOTAM Tetrahydrochloride Hydrate; 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid tetrahydrochloride; DOTAM•4HCl•xH2O; Tetraxetan tetrahydrochloride hydrate; Cyclam tetraacetic acid tetrahydrochloride; 1,4,8,11-Tetraazacyclotetradecane-N,N',N'',N'''-tetraacetic acid tetrahydrochloride hydrate; 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetate tetrahydrochloride
EINECS	Contact for details

Quality Control

Our 1,4,8,11-Tetraazacyclotetradecane-1,4,8,11-Tetraacetic Acid Tetrahydrochloride Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 10.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.