Description

n-[(1S,2S)-2-Amino-1,2-Diphenylethyl]-N'-[(1R)-1-(1-Naphthalenyl)Ethyl]-Thiourea is a high-purity, chiral thiourea derivative with a complex stereochemistry defined by its (S,S) and (R) configurations. This compound is a critical organocatalyst and chiral ligand used in asymmetric synthesis to achieve high enantioselectivity in key bond-forming reactions. It is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly for creating enantiomerically pure intermediates for active pharmaceutical ingredients (APIs).

Application

• Asymmetric Organocatalysis: Acts as a bifunctional catalyst for enantioselective Michael additions, Mannich reactions, and aldol condensations.
• Chiral Ligand Synthesis: Serves as a precursor for constructing complex ligands used in transition metal-catalyzed asymmetric transformations.
• Pharmaceutical Intermediate: Used in the research and scale-up synthesis of chiral drug candidates, especially in neurology and oncology.
• Academic & Industrial R&D: A valuable tool compound for methodological development in synthetic organic chemistry laboratories.
• Resolution Agent: Potential use in the chiral resolution of racemic mixtures due to its ability to form diastereomeric complexes.

Basic Information

Product Name	n-[(1S,2S)-2-Amino-1,2-Diphenylethyl]-N'-[(1R)-1-(1-Naphthalenyl)Ethyl]-Thiourea
CAS No.	313695-70-4
Molecular Formula	C27H27N3S
Molecular Weight	425.59 g/mol
Synonyms	(1S,2S)-N1-[(1R)-1-(Naphthalen-1-yl)ethyl]-N2-(2-amino-1,2-diphenylethyl)thiourea; (S,S)-N-(2-Amino-1,2-diphenylethyl)-N'-(1-(1-naphthyl)ethyl)thiourea; (1R,2S)-N-(2-Amino-1,2-diphenylethyl)-N'-(1-(1-naphthyl)ethyl)thiourea; Chiral Thiourea Organocatalyst; Takemoto Catalyst Derivative; Bifunctional Thiourea Catalyst; Asymmetric Synthesis Catalyst; 1-[(1S,2S)-2-Amino-1,2-diphenylethyl]-3-[(1R)-1-(1-naphthyl)ethyl]thiourea
EINECS	Contact for details

Quality Control

Our n-[(1S,2S)-2-Amino-1,2-Diphenylethyl]-N'-[(1R)-1-(1-Naphthalenyl)Ethyl]-Thiourea is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccant in the storage area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.