Description

3,5-Difluorobenzylzinc Bromide is a highly reactive organozinc reagent, specifically a benzylzinc halide, widely utilized in modern synthetic chemistry for the formation of carbon-carbon bonds. Its core value lies in enabling efficient and selective cross-coupling reactions, such as Negishi coupling, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it serves as a critical building block for introducing the 3,5-difluorobenzyl moiety into target molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the introduction of the difluorobenzyl group in active pharmaceutical ingredients (APIs), particularly in drug discovery and development.
• Negishi Cross-Coupling Reactions: Used as a versatile nucleophile to couple with various electrophiles (e.g., aryl/vinyl halides, triflates) for C-C bond formation under mild conditions.
• Agrochemical Active Ingredient Production: Employed in the synthesis of novel herbicides, fungicides, and insecticides that incorporate fluorinated aromatic systems for enhanced efficacy and stability.
• Ligand and Catalyst Development: Serves as a precursor in the preparation of specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Used to synthesize fluorinated organic compounds for advanced materials, such as liquid crystals, polymers, and organic semiconductors.
• Fine Chemical and Specialty Chemical Manufacturing: Applied in the custom synthesis of complex, high-value fluorinated aromatic compounds for various industrial applications.

Basic Information

Product Name	3,5-Difluorobenzylzinc Bromide
CAS No.	308796-30-7
Molecular Formula	C7H5BrF2Zn
Molecular Weight	280.41 g/mol
Synonyms	(3,5-Difluorophenyl)methylzinc bromide; Zinc, bromo(3,5-difluorobenzyl)-; 3,5-Difluorobenzylzinc bromide solution; Bromo(3,5-difluorobenzyl)zinc; 3,5-Difluorobenzyl zinc bromide; (3,5-Difluorobenzyl)zinc bromide; Benzylzinc bromide, 3,5-difluoro-
EINECS	Contact for details

Quality Control

Our 3,5-Difluorobenzylzinc Bromide is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including titration for zinc content and GC/HPLC for purity and solvent verification. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, hygroscopic (moisture-sensitive), and easily oxidized. It must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions, or as specified on the label. Keep the container tightly sealed in a cool, dry, and well-ventilated place. Handle and open containers only under an inert atmosphere using appropriate techniques to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (in THF or Et2O)	0.5 M (Typical, custom concentrations available)
Assay (Zinc by Titration)	≥ 95%
Purity (GC/HPLC)	≥ 90% (of organozinc species)
Water Content (Karl Fischer)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.