Description

4-Ethoxybenzylzinc Chloride is an organozinc reagent, a versatile building block for organic synthesis. This compound is highly valued for its role in facilitating carbon-carbon bond formation, particularly in cross-coupling reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries to introduce the 4-ethoxybenzyl moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates containing the 4-ethoxybenzyl group.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and specialty polymers.
• Cross-Coupling Reactions: A crucial component in Negishi, Kumada, and other transition-metal-catalyzed coupling reactions to construct complex organic molecules.
• Fine Chemical Production: Used for the custom synthesis of high-value, low-volume specialty chemicals for various industrial applications.

Basic Information

Product Name	4-Ethoxybenzylzinc Chloride
CAS No.	308796-29-4
Molecular Formula	C9H11ClOZn
Molecular Weight	235.99 g/mol
Synonyms	(4-Ethoxybenzyl)zinc chloride; Zinc, chloro(4-ethoxybenzyl)-; 4-Ethoxybenzylzinc chloride solution; p-Ethoxybenzylzinc chloride; (p-Ethoxybenzyl)zinc chloride; 1-Chloro-1-(4-ethoxybenzyl)zinc; Organozinc reagent 308796-29-4
EINECS	Contact for details

Quality Control

Our 4-Ethoxybenzylzinc Chloride is produced under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and solution concentration (typically supplied in THF or ether). We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, residual moisture, and metal content. Our quality management system supports cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated place. Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed and handled under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR/IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (Zinc basis)	≥ 95%
Water Content (Karl Fischer)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.