Description

6-Methyl-2-Pyridylzinc Bromide is a valuable organozinc reagent widely used in modern synthetic chemistry for the formation of carbon-carbon bonds. This compound matters because it offers a stable, reactive source of the 6-methyl-2-pyridyl moiety for cross-coupling reactions, enabling the efficient synthesis of complex heterocyclic structures. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing novel molecular scaffolds.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for introducing the 2,6-disubstituted pyridine motif into potential drug candidates, particularly in kinase inhibitors and other bioactive molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate pyridine-based structures for enhanced efficacy.
• Cross-Coupling Reactions: Employed in Negishi, Kumada, and related palladium or nickel-catalyzed coupling reactions with aryl or vinyl halides to form biaryl systems.
• Ligand Precursor: Serves as a precursor for the synthesis of specialized nitrogen-containing ligands used in catalysis and coordination chemistry.
• Material Science: Utilized in the creation of organic electronic materials and metal-organic frameworks (MOFs) where the pyridyl group acts as a coordinating unit.
• Fine Chemical Production: Applied in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.

Basic Information

Product Name	6-Methyl-2-Pyridylzinc Bromide
CAS No.	308795-98-4
Molecular Formula	C6H6BrNZn
Molecular Weight	237.41 g/mol
Synonyms	2-(6-Methylpyridin-2-yl)zinc bromide; (6-Methylpyridin-2-yl)zinc bromide; 6-Methyl-2-pyridylzinc bromide solution; Zinc, bromo(6-methyl-2-pyridinyl)-; 2-Pyridylzinc bromide, 6-methyl-; Bromo(6-methyl-2-pyridinyl)zinc
EINECS	Contact for details

Quality Control

Our 6-Methyl-2-Pyridylzinc Bromide is produced under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes comprehensive analysis, including titration for zinc content and spectroscopic identification. Certificates of Analysis (COA) detailing purity, concentration (typically supplied as a solution in THF or ether), and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) to prevent decomposition. For solutions, store at 2-8°C in a dedicated flammable storage cabinet or refrigerator. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Zinc Content	Reported on COA
Purity (GC/HPLC)	≥ 95% (by GC, vs. internal standard)
Water Content (KF)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.