Description

Benzenepropanol, 2-(Trifluoromethyl)-, 1-(4-Methylbenzenesulfonate) is a specialized organic intermediate featuring a trifluoromethyl group and a tosylate leaving group, which are critical for its reactivity. This compound matters for its role as a key building block in the synthesis of more complex molecules, particularly in the pharmaceutical and agrochemical sectors where the introduction of fluorine atoms is highly desirable. Industries that require advanced fine chemical synthesis, such as pharmaceutical R&D, agrochemical manufacturing, and material science, need this high-purity intermediate to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders or metabolic diseases where the trifluoromethyl group enhances bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine moiety to improve pesticidal activity and environmental persistence profiles.
• Liquid Crystal & OLED Material Precursor: Acts as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its ability to modify electronic properties.
• Cross-Coupling Reactions: The tosylate group makes it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and creating fluorinated molecular libraries for screening.
• Specialty Polymer Modification: Can be incorporated as a monomer or modifier to introduce fluorine into polymer chains, enhancing properties like chemical resistance, thermal stability, and surface characteristics.

Basic Information

Product Name	Benzenepropanol, 2-(Trifluoromethyl)-, 1-(4-Methylbenzenesulfonate)
CAS No.	308368-65-2
Molecular Formula	C17H17F3O3S
Molecular Weight	358.38 g/mol
Synonyms	2-(Trifluoromethyl)benzenepropanol 1-(4-Methylbenzenesulfonate); 3-[2-(Trifluoromethyl)phenyl]propyl 4-methylbenzenesulfonate; 1-(Tosyloxy)-3-(2-(trifluoromethyl)phenyl)propane; α,α,α-Trifluoro-2-tolylpropanol tosylate; (3-(2-(Trifluoromethyl)phenyl)propyl 4-methylbenzenesulfonate; Tosylate ester of 2-(trifluoromethyl)benzenepropanol
EINECS	Contact for details

Quality Control

Our production of Benzenepropanol, 2-(Trifluoromethyl)-, 1-(4-Methylbenzenesulfonate) CAS 308368-65-2 adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and Karl Fischer titration for moisture content. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements, supporting applications in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H & ¹³C)
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.