Description

2-Chloro-6-Fluorobenzylzinc Chloride is a highly reactive organozinc reagent, a key building block in modern synthetic chemistry. Its value lies in enabling efficient carbon-carbon bond formation, specifically through Negishi cross-coupling reactions, which are critical for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and advanced intermediates. The product is supplied as a solution, typically in tetrahydrofuran, for optimal handling and reactivity.

Application

This organometallic reagent serves as a versatile synthon in advanced organic synthesis. Key applications include:

• Pharmaceutical Intermediate Synthesis: A crucial building block for constructing fluorinated and chlorinated aromatic scaffolds found in active pharmaceutical ingredients (APIs).
• Agrochemical Development: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific halogenated benzyl motifs.
• Negishi Cross-Coupling Reactions: Primarily employed to form new carbon-carbon bonds with a variety of electrophiles, such as aryl halides, in the presence of palladium catalysts.
• Material Science Research: Facilitates the synthesis of specialized ligands, organic semiconductors, and liquid crystals.
• Fine Chemical Production: Enables the precise introduction of the 2-chloro-6-fluorobenzyl group into complex molecules for specialty chemical applications.

Basic Information

Product Name	2-Chloro-6-Fluorobenzylzinc Chloride
CAS No.	307531-98-2
Molecular Formula	C7H5Cl2FZn
Molecular Weight	240.38 g/mol
Synonyms	2-Chloro-6-fluorobenzylzinc chloride solution; (2-Chloro-6-fluorophenyl)methylzinc chloride; Zinc, [(2-chloro-6-fluorophenyl)methyl]chloro-; 2-Chloro-6-fluoro-α-(chlorozincio)toluene; (2-Chloro-6-fluorobenzyl)chlorozinc; 2-Chloro-6-fluorobenzylzinc chloride, 0.5M in THF
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluorobenzylzinc Chloride is manufactured under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as concentration, assay, and impurity profile. We adhere to cGMP guidelines where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and advanced chemical research.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dedicated freezer for organometallics. The solution is moisture-sensitive (hygroscopic) and easily oxidized; ensure containers are sealed with appropriate septa and purged before and after use. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	0.5 M in THF (Typical)
Assay (Titration)	≥ 95%
Identification (IR)	Conforms to structure
Water Content (KF)	≤ 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.