Description

3,5-Difluorophenylzinc Bromide is a highly reactive organozinc reagent, specifically an arylzinc halide, widely used in modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation, particularly in the synthesis of complex fluorinated aromatic compounds which are critical in advanced material and pharmaceutical research. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable and high-purity building block for cross-coupling reactions like Negishi and related catalytic processes.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing the 3,5-difluorophenyl moiety into target molecules during the R&D and production of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and CNS drugs.
• Agrochemical Manufacturing: Used in the synthesis of novel herbicides, fungicides, and pesticides where the difluorophenyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a precursor for creating fluorinated organic semiconductors, liquid crystals, and polymers with tailored electronic and optical properties.
• Negishi Cross-Coupling Reactions: Functions as a superior nucleophilic partner with various organic electrophiles (e.g., aryl halides, vinyl halides) in palladium-catalyzed couplings to form biaryl and other complex structures.
• Synthesis of Fluorinated Liquid Crystals: Employed in the production of advanced display materials for LCDs and OLEDs, where fluorine atoms improve performance metrics.
• R&D for Fluorine-Containing Compounds: A versatile building block in academic and industrial laboratories for exploring new chemical entities in medicinal and material chemistry.

Basic Information

Product Name	3,5-Difluorophenylzinc Bromide
CAS No.	307531-85-7
Molecular Formula	C6H3F2ZnBr
Molecular Weight	258.29 g/mol
Synonyms	Bromo(3,5-difluorophenyl)zinc; Zinc, bromo(3,5-difluorophenyl)-; (3,5-Difluorophenyl)zinc bromide; 3,5-Difluorophenylzinc bromide solution; 3,5-Difluorobenzenezinc bromide; 1,3-Difluoro-5-(bromozincio)benzene; 3,5-Difluorophenyl zinc bromide
EINECS	Contact for details

Quality Control

Our 3,5-Difluorophenylzinc Bromide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high reactivity. Each lot undergoes rigorous analytical testing, including titration for assay determination and advanced spectroscopic methods for identity and purity verification. Certificates of Analysis (COA) detailing all critical parameters are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, and well-ventilated place. Due to its moisture-sensitive and easily oxidized nature, the container should be kept sealed and allowed to reach room temperature before opening to minimize exposure.

Specification

Item	Specification
Appearance	Colorless to light yellow solution (typically in THF)
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (on bromobenzene basis)
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.